Le système opioïde endogène et l’addiction aux drogues1
[The endogenous opioid system and drug addiction]
Rafael Maldonadoa,* aLaboratori de Neurofarmacologia, Departament de Ciències Experimentals i de la Salut,
Universitat Pompeu Fabra, Barcelona, Spain
Résumé
L’addiction aux drogues est une maladie psychiatrique chronique qui conduit à d’importantes altérations adaptatives dans les circuits de récompense du cerveau. Plusieurs systèmes de neurotransmission sont impliqués dans ces modifications. …afficher plus de contenu…

Cette revue rend compte de l’état actuel des connaissances sur la participation de chaque composante du système opioïde endogène dans les propriétés addictives des différentes drogues.
Summary
Drug addiction is a chronic brain disorder leading to complex adaptive changes within the brain reward circuits. Several neurotransmitters, including the endogenous opioid system are involved in these changes. The opioid system plays a pivotal role in different aspects of addiction. Thus, opioid receptors and endogenous opioid peptides are largely distributed in the mesolimbic system and modulate dopaminergic activity within the reward circuits. Opioid receptors and peptides are selectively involved in several components of the addictive processes induced by …afficher plus de contenu…

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